Turkish Archives of Pediatrics
Original Article

Phenylketonuria: A Scoring System for Brain Magnetic Resonance Imaging

1.

Department of Pediatric Radiology, Van Regional Training and Research Hospital, Van, Turkey

2.

Department of Pediatric Metabolism, Van Regional Training and Research Hospital, Van, Turkey

Turk Arch Pediatr 2023; 58: 519-526
DOI: 10.5152/TurkArchPediatr.2023.23081
Read: 188 Downloads: 63 Published: 25 August 2023

Objective: The purpose of our study was to devise a new brain Magnetic Resonance Imaging (MRI) scoring system based on the Loes and modified Loes scores in phenylketonuria (PKU) patients.

Materials and Methods: The brain MRI scans of patients with late diagnosed PKU were evalu- ated retrospectively. Patients’ age at diagnosis, age at which diet started, age at MRI, and, blood phenylalanine (Phe) levels at the time point closest to the MRI were recorded.

Results: Eleven patients aged from 3 to 28 years were included in the study. The median MRI involvement score was 17 (interquartile range = 3). The most involved white matter areas were the parietooccipital areas. There was a significant (P = .046) correlation between the blood Phe level at the timepoint closest to the imaging and the MRI involvement score.

Conclusion: Our study provides insights into the MRI findings and scoring system in PKU patients. We have developed a scoring system based on the widely used Loes and modified Loes scoring systems that can be implemented in clinical practice. Also, our study contributes to the long-forgotten and largely abandoned area-imaging findings in late diagnosed and untreated PKU patients and set the stage for the future research in this field.

Cite this article as: Bako D, Çıkı K. Phenylketonuria: A scoring system for brain magnetic resonance imaging. Turk Arch Pediatr. 2023;58(5):519-526.

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